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What causes deamination in DNA?
Cytosine deamination, like AP site formation, is caused by hydrolysis and is probably present in the DNA extracted from many sources. Interestingly, unlike depurination, the rate of cytosine deamination is slowed in double-stranded DNA as compared to single stranded DNA.
How is uracil detected?
In other methods, UDG is used as a sensor for uracil bases and uracil moieties are detected by gas chromatography–mass spectrometry (GC–MS) ( 25–27 ) or HPLC MS/MS ( 28 ) after derivatization.
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