Where is AP2 synthesized?

ribosomes These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatus to the trans-Golgi network, and from there via small carrier vesicles to their final destination compartment.

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Where are GTPases found?

The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Subsequently, how are gtpases regulated? The GTPase switch is turned on by GEFs, which stimulate dissociation of the tightly bound GDP, and turned off by GAPs, which accelerate the intrinsically sluggish hydrolysis of GTP. For Ras, Rho, and Rab GTPases, this switch incorporates a membrane/cytosol alternation regulated by GDIs and GDI-like proteins.

How many GTPases are there?

GAPs promote GTP hydrolysis, and return Ras to GDP-bound state (“OFF”). To date, 167 small GTPases have been identified in humans (Supplementary Table S1) (Rojas et al., 2012; Liu et al., 2017). We compared the G-domin region of those small GTPases, and found that there exist 5 repeated sequences.