Who should not take selegiline?

Do not take selegiline if you have used narcotic pain medicines (including meperidine, methadone, tramadol, Demerol®, Dolophine®, Ultram®) or an MAO inhibitor (MAOI) (eg, isocarboxazid, linezolid, phenelzine, tranylcypromine, Marplan®, Nardil®, Parnate®, Zyvox®) within the past 14 days.

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And another question, can you overdose on selegiline?

Overdose symptoms may include severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions). Avoid drinking alcohol while you are taking selegiline. How long does selegiline stay in your system? Factors That Influence How Long Emsam (Selegiline) Stays in Your System. From the time of the last dose, the residual effects of selegiline continue to directly influence metabolism and brain chemistry for two to three weeks. This is how long it takes for enzyme production to return to normal.

Does selegiline cause hair loss?

Events reported only once as a cause of discontinuation are ankle edema, anxiety, burning lips/mouth, constipation, drowsiness/lethargy, dystonia, excess perspiration, increased freezing, gastrointestinal bleeding, hair loss, increased tremor, nervousness, weakness, and weight loss. Does selegiline cause weight loss? Key results: Selegiline decreased whole body fat, subcutaneous- and visceral adiposity, measured by CT and epididymal fat weight in the HFS group, compared with HFS placebo animals, without influencing body weight.

Does selegiline help with depression?

At oral doses between 30–60 mg/day (3–6 times greater than that used in the treatment of PD), selegiline has been studied for depression in several clinical studies and found to be effective. At these doses, oral selegiline significantly inhibits MAO-A and MAO-B in the peripheral and central tissues. Is selegiline a good antidepressant? Some reports have shown that oral selegiline treatment can also be effective in treating depression. For example, oral selegiline was effective for treatment-resistant elderly depressive patients at high doses2 and exhibited antidepressant effects on severe refractory depression at more typical dosing regimens.