Is memantine for mild dementia?

Memantine, indicated for moderate to severe Alzheimer disease (AD), is frequently prescribed off-label either alone or with a cholinesterase inhibitor for mild AD and mild cognitive impairment. In 2006, it was prescribed to 19% of patients with mild AD in the United States.

Read more

Can memantine cause seizures?

In clinical trials of NAMENDA, seizures occurred in 0.2% of patients treated with NAMENDA and 0.5% of patients treated with placebo. And another question, can memantine be taken twice a day? For oral dosage form (solution and tablets): Adults—At first, 5 milligrams (mg) once a day. Your doctor may gradually increase your dose as needed. However, the dose is usually not more than 10 mg two times a day.

Does memantine help depression?

No significant side effects were noted during the memantine treatment. We conclude that using memantine in bipolar depression may improve mood, cognitive functioning and quality of life. Consequently, is memantine better than donepezil? Donepezil showed an advantage over memantine in mild-to-moderate AD, whereas memantine was more effective than donepezil in severe AD. The combination therapy of memantine plus donepezil achieved better outcomes than placebo in the CGI.

When is it best to take memantine?

Take this medicine at bedtime unless your doctor tells you otherwise. You may take donepezil and memantine with or without food. Do not crush, chew, or break an extended-release capsule. Swallow it whole. When is memantine best taken? Memantine is usually taken once a day, in the morning, at the same time each day. However, you and your prescriber may decide that it is better for you to take the medicine at another time.